A ‘wonder drug’-- cure for AIDS, dengue, hepatitis, etc

BEHIND THE SCENES

Alfred P. Dizon

(First of three parts)

I was watching Global News Network (GNN) a few nights ago and came upon a program hosted by an irate host ranting against the government and big media networks for not being supportive in airing a “breakthrough” in the cure of AIDS, dengue, hepatitis and other deadly ailments.

The Filipino inventor of the “cure-all drugs,” Dr. Ruben G. Fabunan,said during the interview, the drugs were patented in the United States. These are administered by injection.

In the course of the discussion, it was speculated that big media networks never aired the “wonder drug” as they had big pharmaceutical firms who advertise in their establishments but this is another story.

Anyhow, during the TV program, patients of the medical center in Zambales where Dr.Fabunan had set up his clinic testified they were cured of AIDS, hepatitis and dengue after being injected with the drug. Some were cured after a few hours, others some days or months.   

So as not to “cloud” this story, below is an account of the drug as culled from their website. Just open Fabunan Antiviral Injection in google. The unedited account:

The present invention relates to a therapeutic composition for the treatment of viral infections and a method of administration thereof. More particularly, the invention relates to a therapeutic composition including a substantially water soluble local anesthetic of the ester type injectable and a water soluble glucocorticoid injectable, and to the method of administering said composition to an infected patient.
          

In both Third-world and developing countries and also in developed countries, there is a prevalent need for an economical yet effective viral treatment to both ease human suffering and save lives.

The present invention relates directly to both of these needs since it has been compassionately used to treat and/or cure a number of known pathogenic viruses, including but not limited to human immunodeficiency virus (HIV) causing acquired immunodeficiency syndrome (AIDS),

Dengue fever virus, influenza virus, rhinovirus causing common colds, herpes zoster virus, mumps virus, measles virus, hepatitis virus, conjunctivitis virus, rabies virus, chickenpox virus and other viruses found in equatorial environments common to Third-World and developing countries but also found with increasing prevalence in industrialized nations. To the best of the inventor's knowledge, in medical textbooks or in current clinical practice, there is no treatment, cure or vaccine for the Dengue fever virus.

This invention comes about after many years of field testing, and now over two years of clinical studies at the Fabunan Medical Clinic located in the province of Zambales, the Philippines in Southeast Asia.

Each known virus that has been treated with this composition has shown a remarkably significant improvement and/or curative result with no serious side effects. Routine cases were clinically diagnosed and then treatment began. A patient usually improved and recovered within seventy two hours but, sometimes, more time was needed.

U.S. Pat. No. 5,492,901 issued to Dr. Ruben G. Fabunan, the present inventor, discloses an envenomation antidote for therapeutic use in the treatment of venomous animal bites or stings. The antidote is administered by intramuscular injection and subcutaneous injection along with a slow intravenous injection.

The antidote is comprised of procaine hydrochloride with epinephrine and dexamethasone sodium phosphate. The present invention discloses a formulation of procaine hydrochloride without epinephrine and dexamethasone sodium phosphate and is administered only intramuscularly for, surprisingly, the treatment of viral diseases.

U.S. Pat. No. 5,922,340 discloses a glucocorticosteroid used to prolong the duration of a local anesthetic by using a controlled release material.

U.S. Pat. No. 5,837,729 discloses the use of acetaminophen (Tylenol), an analgesic without anti-inflammatory activity, and derivatives thereof, in the treatment and prevention of HIV infections.

U.S. Pat. No. 5,510,339 discloses the use of a topical anesthetic and a glucocorticoid to treat diseases such as bronchial asthma through inhalation therapy.

U.S. Pat. No. 4,478,822 discloses a system for delivering drugs including dexamethasone and procaine directly to a body cavity.

None of the abovementioned prior art citations, taken singly or in combination, appear to describe the present invention as claimed.

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This invention comprises a generic formulation of procaine hydrochloride and dexamethasone sodium phosphate which is injected intramuscularly at certain dosages and regulated dosing intervals. This formulation has its broad spectrum use in treating viral infections, mainly AIDS, Dengue fever and influenza

Accordingly, it is a general objective of the present invention to provide a treatment for a broad spectrum of viral diseases which is quickly effective, does not induce serious side effects and can be simply administered in multiple, intramuscular, low volume doses.

Another objective of the present invention is to provide a formulation that can be quickly released for general use since the formulation is comprised of FDA approved generic drugs.

It is still another objective of the present invention to provide a treatment for viral diseases where a patient can experience a short recovery time.

Yet another objective of the present invention is to provide a viral disease treatment that is both easily portable and available in packaged form for immediate use. These and other objectives of the present invention will become readily apparent upon further review of the description of the present invention which follows.

The present invention is useful for the effective treatment of viral infections. The viral treatment is prepared from USP approved drugs and has broad application in the treatment of several viral infections, namely AIDS, Dengue fever, influenza, common colds, herpes, mumps, measles, viral hepatitis, conjunctivitis, chickenpox and rabies.

The invention includes a formulation of procaine hydrochloride, USP, combined with dexamethasone sodium phosphate, USP. By itself, procaine hydrochloride is a local anesthetic that blocks the conduction of nerve impulses.

It is readily absorbed following parenteral administration and is directly biotransformed in the bloodstream being hydrolyzed by plasma cholinesterase to para-aminobenzoic acid and diethylaminoethanol within one and one half hours from the time of administration.

Procaine hydrochloride is the ester of diethylaminoethanol and para-aminobenzoic acid and is related chemically and pharmacologically to ester type local anesthetics. The chemical name of procaine hydrochloride is benzoic acid 4-amino, 2-diethly(amino)ethyl ester monohydrochloride. Dexamethasone sodium phosphate is a water-soluble inorganic ester of dexamethasone.

Dexamethasone sodium phosphate, by itself, is used to treat endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergic states, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases and edematous states.

Dexamethasone sodium phosphate has the chemical name 9-fluoro-11β,17,21-trihydroxy-16–-methylpregna- 1,4-diene-3,20-dione 21-(dihydrogen phosphate) disodium salt. It comes as a surprise that procaine hydrochloride and dexamethasone sodium phosphate, when used together, can have a positive effect on the treatment of viral diseases. It is known that certain esters like procaine hydrochloride can act synergistically with esters of dexamethasone to prolong procaine hydrochloride anesthetic activity.

Procaine hydrochloride injection is available as a sterile solution in a concentration of 2% (20 mg of procaine hydrochloride in 1 ml solution).

Dexamethasone sodium phosphate is available as a sterile solution in a concentration of 0.4% (4 mg of dexamethasone sodium phosphate in 1 ml solution).

The present invention includes a formulation comprising a mixture of procaine hydrochloride and dexamethasone sodium phosphate which is injected intramuscularly at certain dosages and regulated dosing intervals depending on the disease type, patient's severity of condition, age, body build and response to treatment. The following dosage schedule provides an indication of average doses and dosing intervals for adults and children:

For AIDS, Dengue fever and influenza treatment, adult patients can receive an intramuscular injection of around 30 mg of procaine hydrochloride in 1.5 ml of a 20 mg/ml solution mixed with around 2 mg of dexamethasone sodium phosphate in 0.5 ml of a 4 mg/ml solution. The total volume of 2 ml comprising the two compound formulation is aseptically transferred into a sterile 2 milliliter syringe.

After the ingredients are gently mixed, the formulation containing syringe is ready for injection. In children, the average dosages are reduce to around 15 mg of procaine hydrochloride in 0.75 ml of a 20 mg/ml solution mixed with around 1 mg of dexamethasone sodium phosphate in 0.25 ml of a 4 mg/mi solution. The total volume of 1 ml comprising the two compound formulation is aseptically transferred to a 1 ml sterile syringe and mixed as described above.

One having ordinary skill in the art will readily recognize that the above ratios and concentrations may be varied and the effect or results may be readily gaged without departing from the spirit and scope of the present invention.”